Maternal childhood emotional abuse increases cardiovascular responses to children's emotional facial expressions.

Parents with a history of childhood maltreatment may be more likely to respond inadequately to their child's emotional cues, such as crying or screaming, due to previous exposure to prolonged stress. While studies have investigated parents' physiological reactions to their children's vocal expressions of emotions, less attention has been given to their responses when perceiving children's facial expressions of emotions. The present study aimed to determine if viewing facial expressions of emotions in children induces cardiovascular changes in mothers (hypo- or hyper-arousal) and whether these differ as a function of childhood maltreatment. A total of 104 mothers took part in this study. Their experiences of childhood maltreatment were measured using the Childhood Trauma Questionnaire (CTQ). Participants' electrocardiogram signals were recorded during a task in which they viewed a landscape video (baseline) and images of children's faces expressing different intensities of emotion. Heart rate variability (HRV) was extracted from the recordings as an indicator of parasympathetic reactivity. Participants presented two profiles: one group of mothers had a decreased HRV when presented with images of children's facial expressions of emotions, while the other group's HRV increased. However, HRV change was not significantly different between the two groups. The interaction between HRV groups and the severity of maltreatment experienced was marginal. Results suggested that experiences of childhood emotional abuse were more common in mothers whose HRV increased during the task. Therefore, more severe childhood experiences of emotional abuse could be associated with mothers' cardiovascular hyperreactivity. Maladaptive cardiovascular responses could have a ripple effect, influencing how mothers react to their children's facial expressions of emotions. That reaction could affect the quality of their interaction with their child. Providing interventions that help parents regulate their physiological and behavioral responses to stress might be helpful, especially if they have experienced childhood maltreatment.

Mifepristone-Misoprostol Use for Second- and Third-Trimester Medical Termination of Pregnancy in a Canadian Tertiary Care Centre.

OBJECTIVE: This study aims to evaluate the impact of the implementation a mifepristone-misoprostol protocol (MIFE/MISO) on the induction-to-expulsion interval in the context of second- and third-trimester pregnancy termination or intrauterine fetal death (IUFD) compared with misoprostol alone (MISO), and to share the experience of a Canadian tertiary hospital concerning the feasibility and safety of such a protocol. METHODS: This is a single-centre retrospective pre-post cohort study carried out at the Centre Hospitalier Universitaire (CHU) Sainte-Justine between 2017 and 2019. Women in the MIFE/MISO group were instructed to take mifepristone 24-48 hours before induction. Induction in the MIFE/MISO group was performed with misoprostol dosages adjusted to gestational age and the presence of previous uterine scars, while, in the MISO group, all patients received 400 µg of misoprostol vaginally every 4 hours. RESULTS: Ninety-four patients were included in the MIFE/MISO group and 103 patients, in the MISO group. Median time to expulsion was significantly lower in the MIFE/MISO group than the MISO group (13.5 and 19.5 h respectively; P < 0.001). The total dose of misoprostol administered was significantly lower in the MIFE/MISO group than the MISO group, and adverse effects were reported in 60% and 82% of patient records, respectively (P < 0.001). Complication rates were similar between the 2 groups. CONCLUSION: The MIFE/MISO protocol is highly effective for second- and third-trimester induction for pregnancy termination or IUFD, without increasing complication rates and with fewer reported adverse effects. Its implementation is safe and feasible in a tertiary medical centre.

Cumulative Contexts of Vulnerability to Intimate Partner Violence Among Women With Disabilities, Elderly Women, and Immigrant Women: Prevalence, Risk Factors, Explanatory Theories, and Prevention.

Some groups of women are more vulnerable to intimate partner violence (IPV) due to particular risks and/or experiences: women with disabilities, elderly women, and immigrant women (DEI). Too often, their reality goes unnoticed, especially for those belonging to more than one of these groups. In this literature review, researchers used an intersectional approach to document the similarities and differences in how DEI women experience IPV, in terms of forms and consequences, as well as related risk factors, explanatory theories, and prevention strategies. Researchers selected 56 articles for review based on the following inclusion criteria: studies on adults living in a situation of IPV, studies on one of the three demographics under study (DEI), studies about one or multiple research questions, and studies based on empirical data relying on research methodology in either French or English. Researchers evaluated each selected article for its quality according to a chart that was specially developed for this review. The results highlight existing "intersections" between these groups to help understand the influence of belonging to more than one vulnerability group on these women's experiences with IPV. The importance to better training social workers and developing policies and programs that target the social determinants of health to prevent IPV experienced by DEI is also discussed.

Inactivation of the riboswitch-controlled GMP synthase GuaA in Clostridioides difficile is associated with severe growth defects and poor infectivity in a mouse model of infection.

Clostridioides difficile is the main cause of nosocomial antibiotic-associated diarrhoea. There is a need for new antimicrobials to tackle this pathogen. Guanine riboswitches have been proposed as promising new antimicrobial targets, but experimental evidence of their importance in C. difficile is missing. The genome of C. difficile encodes four distinct guanine riboswitches, each controlling a single gene involved in purine metabolism and transport. One of them controls the expression of guaA, encoding a guanosine monophosphate (GMP) synthase. Here, using in-line probing and GusA reporter assays, we show that these riboswitches are functional in C. difficile and cause premature transcription termination upon binding of guanine. All riboswitches exhibit a high affinity for guanine characterized by Kd values in the low nanomolar range. Xanthine and guanosine also bind the guanine riboswitches, although with less affinity. Inactivating the GMP synthase (guaA) in C. difficile strain 630 led to cell death in minimal growth conditions, but not in rich medium. Importantly, the capacity of a guaA mutant to colonize the mouse gut was significantly reduced. Together, these results demonstrate the importance of de novo GMP biosynthesis in C. difficile during infection, suggesting that targeting guanine riboswitches with analogues could be a viable therapeutic strategy.

Reasoning strategies explain individual differences in social reasoning.

The dual-strategy model of reasoning suggests that when people reason they can either use (a) a statistical strategy which generates an estimation of conclusion likelihood using a rapid form of associative processing or (b) a counterexample strategy which identifies potential counterexamples to a conclusion using a more conscious working memory intensive process. Previous results suggest that strategy use is a strong individual difference that represents a broad distinction in the way that information is processed that goes beyond deductive reasoning. In 3 studies, we examined if this model could predict individual differences in the processing of social information by examining socially relevant cognitive biases. Study 1 found that strategy use predicted the extent of the self-serving bias. Study 2 found that strategy use predicted use of racist stereotypes even when need for closure was accounted for. Study 3 found that an essentialist prime resulted in a higher level of gender bias among statistical reasoners but that this prime had no effect on counterexample reasoners. These results indicate that the processing distinction between the 2 reasoning strategies underlies individual differences in social biases such as stereotypes, sexism, and racism. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Divergent Thinking Promotes Deductive Reasoning in Preschoolers.

This study explored the hypothesis that preschoolers' deductive reasoning would be improved by encouraging use of divergent thinking (DT). Children of 4-5 years of age (n = 120) were randomly given DT or neutral control exercises before deductive reasoning problems. To allow a stronger test of the hypothesis, half of the children receiving the DT exercises were given explicit examples, which have been shown to reduce ideational originality. Results indicate that, as predicted, DT exercises without examples significantly improved rates of deductive responding, compared to exercises with examples and the control condition. These findings indicate that DT is a key component in the early beginnings of deductive reasoning. Some educational implications are discussed.

The development of fast and slow inferential responding: Evidence for a parallel development of rule-based and belief-based intuitions.

Dual process theories postulate the existence of two levels of processing, Type 1, which uses belief-based cues to make very rapid inferences, and Type 2, which uses more conscious, working memory-based processes that are, in principle, capable of making rule-based judgments. There is a common assumption that Type 1 processes are more rapidly produced, while Type 2 processes take more time. Evidence for this assumption is mixed. Recently, Newman, Gibb, and Thompson (Journal of Experimental Psychology: Learning, Memory, and Cognition, 43(7): 1154, 2017) have provided clear evidence that very fast responses use a combination of both belief-based and rule-based cues. In these studies, we initially replicated this basic result with adults using a different methodology and extended them to examine in greater detail patterns of change with restricted time. The results also show the same combination of rule-based and belief-based cues in fast responses, and suggest that time constraints differentially affect each form of cue. We then examined the developmental pattern of both fast and slow responding. Children aged between 8 and 10 years of age were examined using the methodology of the initial study. Results show that both developmental patterns and the effect of reduced time on children produce parallel changes in both belief-based and rule-based responding. These results suggest the existence of two simultaneously developing processes, consistent with a dual-strategy model of reasoning.

Purine analogs targeting the guanine riboswitch as potential antibiotics against Clostridioides difficile.

Riboswitches recently emerged as possible targets for the development of alternative antimicrobial approaches. Guanine-sensing riboswitches in the bacterial pathogen Clostridioides difficile (formerly known as Clostridium difficile) constitute potential targets based on their involvement in the regulation of basal metabolic control of purine compounds. In this study, we deciphered the structure-activity relationship of several guanine derivatives on the guanine riboswitch and determined their antimicrobial activity. We describe the synthesis of purine analogs modified in ring B as well as positions 2 and 6. Their biological activity was determined by measuring their affinity for the C. difficile guanine riboswitch and their inhibitory effect on bacterial growth, including a counter-screen to discriminate against riboswitch-independent antibacterial effects. Altogether, our results suggest that improvements in riboswitch binding affinity in vitro do not necessarily translate into improved antibacterial activity in bacteria, despite the fact that some structure-activity relationship was observed at least with respect to binding affinity.

High status males invest more than high status females in lower status same-sex collaborators.

Studies on human cooperation using economic games rarely include ecologically relevant factors. In studies on non-human primates however, both status and sex typically influence patterns of cooperation. Across primate species, high status individuals are more likely to cooperate, though this depends on the species-specific social structure of each sex. Based on human social structure, we predict that higher status males who interact more in hierarchical groups than females, will invest more than high status females in valued same-sex peers after successful cooperation. Across three studies, 187 male and 188 female participants cooperated with a (fictitious) same-sex partner who varied in competence. Participants then divided a reward between themselves and their partner. High status was induced in three different ways in each study, social influence, leadership and power. No overall sex difference in reward sharing was observed. Consistent with the hypothesis however, across all three studies, high status males invested more than high status females in cooperative partners, suggesting that high status males intuitively evaluate sharing rewards with same-sex partners as more beneficial.